This histogram shows the distribution of raw p-values for all genes tested in the differential expression analysis. The x-axis represents the p-value, and the y-axis shows the number of genes in each bin. A uniform distribution suggests that none or only a small percentage of genes are differentially expressed, while a peak near zero (i.e., anti-conservative p-values) indicates that some genes are truly differentially expressed. This plot is a quick way to evaluate the strength of the signal in your data.